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Четверг, 2012 Октябрь 11, 02:02
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Erectile dysfunction treatment: Levitra
Levitra (Vardenafil), commercially available as of March 2003, is effective from 30 min after administration. Its effect is reduced by a heavy, fatty meal (> 57% fat). It is administered in 5, 10 and 20 mg doses. The recommended starting dose is 10 mg and should be adapted according to the patient’s response and side-effects. After 12 weeks in a dose-response study, improved erections were reported by 66%, 76% and 80% of men taking 5 mg, 10 mg and 20 mg of levitra vardenafil, respectively, compared with 30% of men taking placebo. Vardenafil statistically improved patient scores for IIEF, SEP2, SEP3, and GAQ and treatment satisfaction. Efficacy was confirmed in post-marketing studies. Vardenafil improved erections in difficult-to-treat subgroups. In diabetic patients, 72% reported improved erections (i.e. improved GAQ) compared Oral phosphodiesterase type 5 (PDE5) inhibi-tors are recommended as first-line therapy for the treatment of ED to 13% of patients taking placebo and the final IIEF-EF score was 19 compared to 12.6 for.
Physiology of erectile function and dysfunction
Vardenafil HCl (Levitra™) has a half-life of 4.7 h, a value not dissimilar from that of sildenafil 100 mg (Viagra®). At a dose of 20 mg, up to 85% of men reported significant improvement in erections at 26 weeks compared with 28% of men who received placebo. Similar to sildenafil, vardenafil seems effective even in challenging patient groups such as those with diabetes mellitus (Figure 65) or post-prostatectomy erectile dysfunction (Figure 66). Side-effects include headache and facial flushing, and, like sildenafil (Viagra®) and tadalafil (Cialis™), vardenafil (Levitra™) should not be used in conjunction with any form of nitrate therapy. Because of its mild hypotensive effect, vardenafil (Levitra™) should not be taken in conjunction with ?-blockers, such as terazosin. In addition, vardenafil (Levitra™) has been shown to produce minor prolongation of the QT interval and, as a consequence, should be avoided in patients with congenital QT prolongation and those taking Class 1A (e.g. quinidine, procainamide) or Class III (e.g. amiodarone, sotalol) antiarrhythmic medications. Buy levitra next day delivery
PDE5 inhibitors: Vardenafil, Sildenafil, Tadalafil
Tadalafil (cheap Cialis) has a mean half-life of 17.5 h and has been reported; at a dose of 20 mg, to enable 73–80% of sexual intercourse attempts to be completed successfully (with appropriate sexual stimulation) between 30 min and 36 h after dosing. Tadalafil was administered without restrictions to alcohol or food intake, although substantial alcohol consumption is not recommended. Therapy was well tolerated; with an overall incidence of side-effects such as headache and dyspepsia of 2.1% compared with 1.3% for placebotreated patients. Tadalafil is contraindicated with organic nitrates—and at least 48 h must elapse after taking tadalafil before their administration. With the exception of once-daily tamsulosin (Flomax®) 0.4 mg, it is also contraindicated with ?-blocker therapy.
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